Clinical Trial Simulation
The current situation
Conducting successful clinical trials is a significant component of the product development process for pharmaceutical, biotechnology, diagnostic, and medical device companies. Clinical trials require a significant investment of time and resources. Thus, it is critical to design a trial that yields conclusive and meaningful results and whose probability of success has been maximized.
The Archimedes advantage
The Archimedes Model is a comprehensive, validated simulation model of human physiology, diseases, clinical care interventions, patient and physician behaviors, and healthcare systems. It has been in development since 1993 and has demonstrated its value to nine of the top ten pharmaceutical organizations worldwide.
By simulating clinical trials before implementing them, companies can:
- Improve sample size estimation by better understanding baseline/control arm event rates
- Sharpen estimates of size and composition of eligible population
- Improve a trial’s probability of success, for example by forecasting cardiovascular outcomes and safety studies
- Preview possible trial outcomes in simulated healthcare systems where patients do not always take medications and physicians to not always follow guidelines
Through our partnership with Quintiles our customers have access to a large pool of global experts.
How you can use the Archimedes Model
ARCHeS – ARCHeS is a comprehensive web-based tool that gives you direct access to most of the power of the Archimedes Model. It enables you to set up and run your own clinical trial simulations. With ARCHeS, you can examine conditions, treatments, and outcomes related to coronary artery disease, stroke, diabetes and its complications, obesity, hypertension, and dyslipidemia. It can also be used to create and explore new or hypothetical treatments, either by drawing on the results of phase 2 clinical trials or by specifying effects on biomarkers (i.e., pharmacodynamic effects) and/or health outcomes.
Modeling & Consulting Services – ARCHeS is currently limited to simulations related to cardio-metabolic risk. However the Archimedes Model spans a wider range of diseases, including multiple cancers and asthma. For clinical trial simulations that cannot be addressed with ARCHeS Innovator, or for novel diseases not yet in the Model, we have dedicated modeling teams to design and run custom clinical trial simulations. We can help you quantify expected events to appropriately power a trial or to answer complex questions about the effects of interventions on specific populations.
Webinar and Case Studies
See how the Model is used for trial simulation: register for immediate access to our archived webinar and case studies.
