Specifications
Left Column Title:
Cardio-Metabolic Risk dataset specifications
Left Column Content:
Interventions
The Cardio-Metabolic Risk dataset contains the results of 19 simulated controlled trials that compare current levels of care ("standard care") with three main types of interventions:
- "Magic Pills": These are hypothetical treatments created to achieve precisely the objective of a guideline or prevention recommendation. They include interventions for controlling BMI, SBP, LDL, smoking, FPG, and HbA1c to specified levels.
- Achievement of 100% adherence to guidelines: These interventions deliver care as specified in current guidelines, including steps to add or switch drugs as indicated by a guideline to try to reach a goal.
- Specific drugs. Three of the trials involve specific drugs (Metformin, aspirin, and a polypill of aspirin, a statin, and a beta blocker).
Population
- 100,000 individuals age 30-85 representative of the U.S. population. (Source: National Health and Nutrition Examination Survey (NHANES) 1999 – 2006)
Right Column Content:
Study settings
- Ambulatory, outpatient, and inpatient care practices based on national guidelines
- Adherence to guidelines calibrated to match actual levels of care in the U.S.
- Costs based on Medicare datasets
- Quality-of-life assumptions based on Sullivan and Ghushchyan 2006, Coffey et al. 2002
Outcomes
- Diagnoses of MI, stroke, MACE, revascularization, diabetes, diabetic proliferative retinopathy, bilateral blindness, ESRD, diabetic foot ulcer, diabetic foot amputation
- Total deaths, CHD deaths, stroke deaths
- Life years, quality adjusted life years (QALYs), discounted QALYs
- Medical costs
- Biomarkers and risk factors
- Utilization
